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目的 :探讨高脂蛋白血症患者血浆中可溶性细胞粘附分子 1(sICAM 1)与甘油三酯 (TG)、低密度脂蛋白胆固醇 (LDL C)、总胆固醇 (TC)、脂蛋白a(Lp a)、高密度脂蛋白胆固醇 (HDL C)的相互关系及临床意义。方法 :经体检排除心肌梗死、脑卒中、短暂性脑缺血、癌症、严重肝肾疾病的患者 16 0例 ,空腹采血。用ELISA方法测定sICAM 1,全自动生化分析仪测定血脂。结果 :①高脂蛋白血症患者血浆中sICAM I水平与TG(r =0 .15 ,P <0 .0 1)、LDL C(r =0 .16 ,P <0 .0 1)水平呈正相关 ;②高脂蛋白血症患者血浆中sICAM 1水平与HDL C(r =- 0 .15 ,P <0 .0 1)水平呈负相关。结论 :sICAM 1可能是早期动脉粥样硬化性疾病的标志 ,也可能是致病的病因基础
Objective: To investigate the relationship between plasma sICAM 1 and triglyceride (TG), low density lipoprotein cholesterol (LDL C), total cholesterol (TC), lipoprotein a (Lp) in patients with hyperlipoproteinemia a), high density lipoprotein cholesterol (HDL C) and its clinical significance. Methods: 160 cases of patients with myocardial infarction, stroke, transient ischemic attack, cancer and severe liver and kidney disease were excluded by physical examination. Fasting blood was collected. SICAM 1 was measured by ELISA and blood lipids were measured by automatic biochemical analyzer. Results: ① The plasma levels of sICAM I in patients with hyperlipoproteinemia were positively correlated with the levels of TG (r = 0.15, P <0.01) and LDL C (r = 0.16, P <0.01) ; ②The level of sICAM 1 in plasma of patients with hyperlipoproteinemia is negatively correlated with the level of HDL C (r = - 0.15, P <0.01). Conclusion: sICAM 1 may be a marker of early atherosclerotic disease and may also be the causative basis of the disease