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目的:探讨广谱抗肿瘤新药榄香烯局部用药治疗颅内恶性肿瘤的效果;方法:局部用药治疗颅内恶性肿瘤19例(男11例、女8例,年龄11~61岁),共中恶性胶质瘤17例,脑转移瘤2例。采用经颅穿刺多点注药,有囊性变者先抽取囊液后,囊内注药。剂量:实质性肿瘤目的:探讨广谱抗肿瘤新药榄香烯局部用药治疗颅内恶性肿瘤的效果;方法:局部用药治疗颅内恶性肿瘤19例(男11例、女8例,年龄11~61岁),共中恶性胶质瘤17例,脑转移瘤2例。采用经颅穿刺多点注药,有囊性变者先抽取囊液后,囊内注药。剂量:实质性肿每次2~10mL,有囊液时注入量应少于抽出囊液量,1~2次/周,4次为一个疗程;结果:多数病人症状明显缓解。肿瘤消失(CR)者4例(21.05%)。肿瘤缩小50%者(PR)10例(52.63%),总缓解率(CR+PR)为73.68%,治疗前后肿瘤平均缩小54.04%(p<0.01);结论:榄香烯经肿瘤局部多点注射治疗颅内恶性肿瘤疗效显著,操作简单易行,副作用小,值得临床推广应用,但适应症应有所选择
Objective: To investigate the efficacy of broad-spectrum anti-tumor drug Elemene in the treatment of intracranial malignancies. Methods: Localized treatment of 19 cases of intracranial malignancies (11 males and 8 females, aged 11 to 61 years). There were 17 cases of malignant gliomas and 2 cases of brain metastases. Transcranial puncture multi-point injection, cystic change first cyst fluid, capsule injection. Dose: Substantial tumor Purpose: To investigate the effect of broad-spectrum anti-tumor drug Elemene on topical treatment of intracranial malignancies. Methods: Localized treatment of 19 cases of intracranial malignancies (11 males and 8 females, aged 11 to 61 Aged), a total of 17 cases of malignant glioma, brain metastases in 2 cases. Transcranial puncture multi-point injection, cystic change first cyst fluid, capsule injection. Dosage: Substantial swelling every 2 ~ 10mL, when the amount of cyst fluid injection should be less than the amount of cyst fluid, 1 ~ 2 times / week, 4 times for a course of treatment; Results: Most patients significantly relieved symptoms. Four cases (21.05%) of tumors disappeared (CR). 50% of tumors were reduced (PR) in 10 cases (52.63%), and the total remission rate (CR+PR) was 73.68%. Before and after treatment, the average tumor size was reduced by 54.04% (p<0.01); Conclusion: Elm Treatment of intracranial malignancies with multiple local injections of the tumor is effective, simple and easy to perform, with little side effects, and is worthy of clinical application. However, indications should be selected