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对亚硒酸钠预防甲基硝基亚硝基胍（ＭＮＮＧ）所致胃粘膜细胞损伤的作用进行研究。结果发现，胃粘膜细胞先用１×１０－５ｍｏｌ／Ｌ或１×１０－６ｍｏｌ／Ｌ亚硒酸钠预处理４ｈ，再给ＭＮＮＧ组细胞的增殖速率、软琼脂集落形成能力、非程序ＤＮＡ合成水平、质脂过氧化物和ｒａｓｐ２１蛋白含量均显著低于ＭＮＮＧ组（Ｐ＜０．０５～０．０１）。结果提示，一定剂量亚硒酸钠对ＭＮＮＧ诱导的胃粘膜细胞损伤有防护作用
The effect of sodium selenite on prevention of gastric mucosal cell injury induced by methylnitroso-nitrosoguanidine (MNNG) was studied. The results showed that gastric mucosal cells were pre-treated with 1 × 10-5mol / L or 1 × 10-6mol / L sodium selenite for 4h, and then the proliferation rate of MNNG cells, ability of colony formation of soft agar and non-programmed DNA synthesis Levels, lipid peroxidation and rasp21 protein content were significantly lower than MNNG group (P <0.05 ~ 0.01). The results suggest that certain doses of sodium selenite have a protective effect on MNNG-induced gastric mucosal cell injury