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正确估样计本含量是医学科研中的一个重要问题.片面追求大样本除可造成人力、物力和财力的浪费外,又易出现假阳性结果。反之,若忽视应当保证的足够样本数,又可导致设计的检验效能(Power)偏低,而易出现假阴性结果。对中华医学杂志、中华血液学杂志、中华消化杂志、中华儿科杂志、解放军医学杂志3年(1988～1990)年,中华传染病杂志3年(1988～1990年),刊登的非手术治疗性研究
It is an important issue in medical research to correctly estimate the content of the sample plan. In addition to the large sample size, it can cause waste of manpower, material resources, and financial resources, and it is prone to false positive results. Conversely, ignoring a sufficient number of samples that should be guaranteed can lead to a low design power and a false negative result. Three years (1988-1990) of Chinese Medical Journal, Chinese Journal of Hematology, Chinese Journal of Digestive Medicine, Chinese Journal of Pediatrics, and People’s Liberation Army Medical Journal, non-surgical therapeutics published in Chinese Journal of Infectious Diseases for 3 years (1988-1990)