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五加心宁胶囊以０ ．７５ ，１ ．５ ，３ ．０ ｇ／ｋｇ 剂量，连续９０ ｄ 灌胃给药于大白鼠。在观察期内，大白鼠一般状态、外观、行为活动及饮食与对照组比较均未见明显差别；体重增长、血象、尿液、肝、肾功能及血液生化指标与对照组比较无明显差异；心、肺、肝、脾、肾、肾上腺、睾丸或卵巢等脏器的肉眼及光镜下病理学检查，均未见药物损伤性病理改变。表明五加心宁胶囊预定临床口服日用量是安全的。
Five plus heart capsules to 0. 75,1. 5,3. A dose of 0 g/kg was given to the rats by gavage for 90 days. During the observation period, there was no significant difference in the general state, appearance, behavior and diet of the rats compared with the control group; there was no significant difference in body weight gain, blood, urine, liver, kidney function, and blood biochemical parameters between the control group and the control group; No pathological changes were found in the pathological examination of the heart, lung, liver, spleen, kidney, adrenal gland, testis, or ovary under the naked eye and under light microscope. It is shown that the scheduled daily oral dose of Wujiaxining capsule is safe.