趋化因子受体是由7个跨膜区组成的G蛋白偶联受体,多个系统的肿瘤细胞均表达趋化因子受体,其在肿瘤的发生、发展和转移等各个阶段都发挥重要作用。近年来有不少研究发现趋化因子受体中的CXCR1和CXCR2与肿瘤关系密切,认为其可能成为肿瘤治疗的一个潜在新靶点。本文就CXCR1和CXCR2这两种趋化因子受体与肿瘤的关系做一综述。 Chemokine receptors are G protein-coupled receptors composed of seven transmembrane domains that express chemokine receptors in multiple systems of tumor cells that play an important role in various stages of tumorigenesis, development, and metastasis effect. In recent years, many studies have found that CXCR1 and CXCR2 in chemokine receptors are closely related to the tumor, which may become a potential new target for cancer therapy. This article reviews the relationship between the chemokine receptors CXCR1 and CXCR2 and tumors.