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高原肺水肿多发生在到达高原后12—72小时。其发生机制多数学者认为是由于缺氧所引起的肺血管非一致性收缩,造成肺灌流不均,在局部肺循环毛细血管内压增高并合并过渡灌流的部位,液体从毛细血管渗出引起。但直到目前尚不能复制出满意的动物模型。因此我们采取事先切除动物一侧肺,从而增加剩余肺的血液灌流量,以试图复制高原肺水肿模型。实验前两周,外科手术方法切除大白鼠左肺,左肺平均占总肺重35％,这就意味着在心
High altitude pulmonary edema occurred more than 12-72 hours after reaching the plateau. The mechanism most scholars believe is due to hypoxia caused by pulmonary vascular inconsistent contraction, resulting in uneven perfusion of the lungs in the local pulmonary capillary pressure and merge with the transitional perfusion site, fluid leakage from the capillaries caused. However, until now it has not been possible to reproduce a satisfactory animal model. Therefore, we take the animal side of the lungs prior to resection, thereby increasing the remaining lung blood perfusion in an attempt to copy high altitude pulmonary edema model. Two weeks before the experiment, surgical removal of left lung in rats, left lung average lung weight 35%, which means in the heart