外源物质的基因毒性作用可能是上呼吸消化道的粘膜形成肿瘤的一个原因。在活体中的毒性物质可通过反复和长期的作用损害靶器官 ,而慧谱分析法仅限于分析离体培养的组织细胞 ,但使用培养的细胞或淋巴细胞进行研究 ,又不能反映活体中复杂的 DNA损害和修复 ,因此设计了一个微器官 The genotoxic effect of exogenous substances may be one of the causes of mucosal tumor formation on the upper respiratory tract. Toxic substances in the living body can damage the target organ by repeated and long-term effects, while the wisdom spectrum analysis method is limited to the analysis of cultured cells in vitro, but the study using cultured cells or lymphocytes can not reflect the complex DNA damage and repair, so the design of a micro-organ