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环磷酸腺苷(cAMP)与环磷酸鸟苷(cGMP)为细胞内参与传递信息和调节细胞功能的核苷酸,故又称为“第二信使”。大量动物实验与离体支气管平滑肌研究,为探讨支气管哮喘的发病与cAMP和cGMP的关系提供了科学根据,但临床报告不多。我们测定了9例急性发作期与23例缓解期支气管哮喘者血浆cAMP与cGMP。摘要报道如下;
Cyclic cAMP and cGMP are also intracellular nucleotides involved in transmitting information and regulating cellular functions, so they are also called “second messengers.” A large number of animal experiments and in vitro bronchial smooth muscle, in order to explore the incidence of bronchial asthma and cAMP and cGMP provide a scientific basis, but few clinical reports. We measured plasma levels of cAMP and cGMP in 9 patients with acute exacerbation and 23 patients with remission of bronchial asthma. The summary is reported below.