目的通过分析86例先天性心脏病(CHD)合并肺动脉高压(PH)孕妇所生产新生儿临床资料,探讨孕妇CHD合并PH对新生儿的影响。方法回顾性分析2003年1月至2013年10月收治的86例CHD合并PH产妇所生新生儿的临床资料,同时选取同期妊娠合并CHD不伴有PH的孕妇所生83例新生儿、以及同期孕检正常无妊娠合并症的孕妇的135例新生儿为对照组,分析比较三组新生儿出生体重、身长,以及早产儿、小于胎龄儿(SGA)、窒息的发生率。采用SPSS17.0统计软件进行统计学分析。结果 86例CHD合并PH孕妇新生儿平均出生体重、身长、早产儿发生率、SGA发生率、新生儿窒息发生率,同83例妊娠合并CHD不伴有PH的孕妇所生新生儿平均出生体重、身长、早产儿发生率、SGA发生率、新生儿窒息发生率,以及同期孕检正常无妊娠合并症的孕妇的135例新生儿平均出生体重、身长、早产儿发生率、SGA发生率、新生儿窒息发生率比较有统计学差异(P<0.05)。孕妇PH分级:轻度35例(40.7%),中度21例(24.4%),重度30例(34.9%)。CHD合并PH的孕妇中PH轻度组、中度组、重度组新生儿出生体重、身长,三组间比较具有统计学意义(P<0.05)。结论 CHD合并PH孕妇所生产的新生儿,出生体重和身长低于正常孕妇新生儿,而且低于CHD不伴有PH孕妇的新生儿;CHD伴PH孕妇其早产儿、SGA、新生儿窒息的发生率均明显升高;尤其CHD合并重度PH孕妇的新生儿窒息、SGA的发生率明显增多。 Objective To analyze the clinical data of 86 newborns born in 86 pregnant women with congenital heart disease (CHD) complicated by pulmonary hypertension (PH) and explore the effect of CHD combined with PH on the newborn infants. Methods The clinical data of 86 newborns with CHD combined with PH maternal birth admitted to our hospital from January 2003 to October 2013 were analyzed retrospectively. Totally 83 newborns were enrolled in the same period pregnant women with CHD without PH, 135 pregnant women with normal pregnant women without pregnancy complications were selected as the control group. The birth weight, length, and the incidence of premature infants, small gestational age children (SGA) and asphyxia were compared and analyzed. SPSS17.0 statistical software was used for statistical analysis. Results The average birth weight, length, premature infant, SGA incidence, neonatal asphyxia incidence in 86 pregnant women with CHD combined with PH were the same as those in 83 pregnant women with CHD without PH, The average birth weight, length, premature infant, incidence of SGA, newborns, newborns, newborns, newborn infants The incidence of asphyxia was statistically significant (P <0.05). PH grade of pregnant women: mild in 35 cases (40.7%), moderate in 21 cases (24.4%) and severe in 30 cases (34.9%). The weight, body length of newborns in PH group, moderate group and severe group with CHD combined with PH were statistically significant among the three groups (P <0.05). Conclusions The neonates born in CHD combined with PH pregnant women have lower birth weight and lower birth weight than those of normal pregnant women and are lower than those of newborns whose CHD is not associated with PH pregnant women. CHD with PH pregnant women have their premature children, SGA and neonatal asphyxia Rate were significantly increased; especially CHD with severe PH pregnant women, neonatal asphyxia, SGA significantly increased the incidence.