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目的:研究二甲双胍片联合糖脉康颗粒对2型糖尿病患者血清白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、脂联素(APN)水平的影响。方法:选择2013年2月至2016年10月在我院接受治疗的2型糖尿病患者130例,按照给药方法不同分为对照组和观察组,对照组采用二甲双胍片治疗,观察组以对照组为基础联合糖脉康治疗。治疗8周后,对比两组患者治疗前后血清IL-6、TNF-α、CRP、APN、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C),空腹血糖(FBC)、餐后2小时血糖(2hPBG)、糖化血红蛋白(HbAlc)、胰岛抵抗指数(HOMA-IR)、胰岛β细胞分泌功能指数(HOMA-IS)和胰岛素敏感指数(ISI)的变化。结果:治疗后,两组患者血清IL-6、TNF-α、CRP、TC、TG、LDL-C,FBC、2hPBC、HbAlc,HOMA-IR均较治疗前均明显降低,而血清APN、HDL-C、HOMA-IS、ISI均明显增高(P<0.05);与对照组相比,观察组患者血清IL-6、TNF-α、CRP、TC、TG、LDL-C,FBC、2hPBC、HbAlc、HOMA-IR水平均较低(P<0.05),血清APN、HDL-C,HOMA-IS、ISI水平较高(P<0.05)。结论:二甲双胍片联合糖脉康治疗2型糖尿病患者可有效稳定其血脂血糖,改善胰岛功能,可能与其降低血清IL-6、TNF-α、CRP水平,增加血清APN水平有关。
Objective: To investigate the effect of metformin tablet and Tangmaikang granule on the levels of serum interleukin-6, tumor necrosis factor-α (TNF-α), C-reactive protein (CRP) and adiponectin (APN) in type 2 diabetic patients Impact. Methods: 130 patients with type 2 diabetes who were treated in our hospital from February 2013 to October 2016 were divided into control group and observation group according to different administration methods. The control group was treated with metformin tablets. The control group As the basis for the treatment of candy pulse Kang. After 8 weeks of treatment, the levels of serum IL-6, TNF-α, CRP, APN, total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL- HDL-C, FBC, 2hPBG, HbAlc, HOMA-IR, HOMA-IS, And insulin sensitivity index (ISI) changes. Results: The levels of IL-6, TNF-α, CRP, TC, TG, LDL-C, FBC, HbAlc and HOMA-IR of the two groups were significantly lower than those before treatment The levels of IL-6, TNF-α, CRP, TC, TG, LDL-C, FBC, 2hPBC, HbAlc in the observation group were significantly higher than those in the control group HOMA-IR levels were lower (P <0.05), serum APN, HDL-C, HOMA-IS, ISI levels were higher (P <0.05). CONCLUSION: Metformin tablets combined with Tangmaikang can effectively stabilize the blood-lipid and blood glucose of type 2 diabetic patients and improve the islet function, which may be related to the decrease of serum IL-6, TNF-α and CRP levels and the increase of serum APN levels.