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目的 为探索小儿急性白血病合并医院感染的防治措施。方法 对17 年587 例患者进行回顾性分析。结果 医院感染发生率43.4% ,从1980～1993 年医院感染率随着化疗强度增强而增加,但1994 年用粒细胞刺激因子(G-CSF)后下降。结论 应用G-CSF、消毒、隔离、改善环境卫生能降低医院感染;大部分医院感染细菌对头孢霉素、丁胺卡那霉素较敏感,对青霉素、庆大霉素、红霉素、氯霉素耐药。
Objective To explore the prevention and treatment of childhood acute leukemia with nosocomial infection. Methods A retrospective analysis of 587 patients over 17 years was performed. Results The incidence of nosocomial infection was 43.4%. From 1980 to 1993, the nosocomial infection rate increased with the increase of chemotherapy intensity. However, the nosocomial infection rate was decreased after using granulocyte stimulating factor (G-CSF) in 1994. Conclusion G-CSF, disinfection, isolation and improvement of sanitation can reduce nosocomial infections. Most of the nosocomial bacteria are sensitive to cefotaxime and amikacin, but have no effect on penicillin, gentamicin, erythromycin, Drug resistance.