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目的为了估价甲肝减毒活疫苗在接种乙肝疫苗免疫失败儿童中的致免疫性和牛磺酸对该疫苗免疫性的影响。方法应用随机对照临床试验。选择９０名健康儿童随机分成二组：４３名接种甲肝减毒活疫苗和口服牛磺酸（Ⅰ组）；４７名接种疫苗加口服安慰剂（Ⅱ组）。另选择６２名由携带ＨＢＶ的无症状母亲所生接种过乙肝疫苗但是免疫失败者（Ⅲ组）和４４名同龄由ＨＢｓＡｇ阴性母亲所生接种乙肝疫苗正常免疫反应的健康儿童（Ⅳ组），均接种甲肝减毒活疫苗作比较。所有对象均除外甲肝感染，接种后观察反应，２个月后检测血清－ＨＡＶＩｇＧ抗体。结果Ⅰ组抗ＨＡＶＩｇＧ平均值显著高于Ⅱ组（ｔ＝７．１０９，Ｐ＜０．０１）；Ⅳ组接种甲肝疫苗后抗－ＨＡＶＩｇＧ平均值与Ⅲ组比较，差异有显著性，（ｔ＝１．９９８，Ｐ＜０．０５）。结论接种乙肝疫苗免疫失败儿童接种甲肝减毒活疫苗的免疫效果比健康儿童差。甲肝减毒活疫苗接种后随访未发现明显副反应。牛磺酸对疫苗接种效果的辅助作用值得推广应用。
Objective To assess the immunogenicity of taurine and live attenuated attenuated hepatitis A vaccine in children immunocompromised for hepatitis B vaccination. Methods Randomized controlled clinical trials. Ninety healthy children were randomly divided into two groups: 43 live attenuated live attenuated hepatitis A vaccine and oral taurine (group Ⅰ); 47 were vaccinated plus oral placebo (group Ⅱ). Another 62 healthy children (Group IV) who were vaccinated with HBV-infected asymptomatic mothers but failed in immunization (group Ⅲ) and 44 normal-born HBsAg-negative mothers were immunized Inoculation of attenuated live attenuated hepatitis A vaccine for comparison. All subjects except Hepatitis A were infected and the response was observed after inoculation. Serum-HAVIgG antibody was detected after 2 months. Results The average value of anti-HAV IgG in group I was significantly higher than that in group II (t = 7.109, P <0.01). The mean of anti-HAV IgG in group IV was significantly higher than that in group III (t = 1.998, P <0.05). Conclusion The immunization effect of live attenuated attenuated hepatitis A vaccine in children vaccinated with hepatitis B vaccine is worse than that of healthy children. Live attenuated hepatitis A vaccination after vaccination found no significant side effects. Taurine on the vaccination effect of the auxiliary role worthy of promotion and application.