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观察杂种犬溴莫普林经口给药１３周的毒性反应，以评估其用药安全性。试药剂量为４０、２０、１０．０及０ｍｇ／（ｋｇｄ），按新药临床前毒理研究规范进行，并增加了骨髓涂片的细胞学检查及血清Ｎａ＋、Ｋ＋、Ｃｌ－离子检测。结果主要毒副反应有呕吐，腹泻，红细胞计数及血红蛋白下降，网织红细胞增多，ＡＬＴ、ＡＳＴ、Ｃｒｅａ升高，肝脏及肾脏出现细胞变性坏死、炎症细胞浸润，骨髓细胞增生活跃，幼红细胞增多，粒红比值下降。在４周停药期可基本恢复，无延迟性毒性反应。结论：溴莫普林犬１３周给药的无毒剂量为１０ｍｇ／（ｋｇｄ），中毒剂量为４０ｍｇ／（ｋｇｄ），毒性靶器官为肝、肾、血液及骨髓的红细胞系统。
To observe the toxic reaction of brimopram mixed oral administration for 13 weeks to evaluate its drug safety. The test doses were 40, 20, 10.0 and 0 mg / (kgd), according to the preclinical toxicology research standards of new drugs, and increased cytological examination of bone marrow smears and serum Na +, K +, Cl- ion detection. Results The main toxic and side effects were vomiting, diarrhea, red blood cell count and hemoglobin, reticulocyte increased, ALT, AST, Crea increased, liver and kidney cell degeneration and necrosis, inflammatory cell infiltration, bone marrow hyperplasia, Granule ratio decreased. In 4 weeks withdrawal period can be basically restored, non-delayed toxicity. Conclusion: The non-toxic dose of 10 mg / (kgd) and the poisoning dose of 40 mg / (kgd) for 13 weeks in the brimoprin dogs are toxic target organs of the liver, kidney, blood and bone marrow of the erythrocyte system.