胎肝中存在着一类低分子抑瘤物,可明显抑制 HL-60细胞的增殖。为探讨其作用机制,本实验对 HL-60细胞经胎肝低分子抑瘤物和维生素 A 酸作用后 c-myc 癌基因的表达水平进行了检测。结果表明,维生素 A 酸可明显抑制 HL-60细胞中 c-myc 基因的表达,而胎肝低分子抑瘤物却无明显作用。 There is a kind of low molecular weight tumor suppressor in fetal liver, which can obviously inhibit the proliferation of HL-60 cells. In order to explore its mechanism of action, we examined the expression of c-myc oncogene in HL-60 cells treated with low molecular weight tumor suppressor and vitamin A acid. The results show that vitamin A acid can significantly inhibit the expression of c-myc gene in HL-60 cells, while fetal liver low molecular weight tumor suppressor has no significant effect.