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目的:观察应用前列地尔联合甲钴胺治疗糖尿病周围神经病变(DPN)的临床疗效及安全性。方法:将2010年6月~2012年10月收治的43例DPN患者在控制血糖、血脂等常规治疗基础上,给予肌肉注射甲钴胺500μg.d~(-1),qd,同时静脉滴注前列地尔100μg.d~(-1),qd,疗程4周。比较治疗前后的疗效及神经传导功能改善情况。结果:本组43例DPN患者,经过4周治疗后显效24例(55.8%),有效14例(32.6%),无效5例(11.6%),总有效率88.4%;与治疗前比较,治疗后神经传导速度(NCV)变化均有明显提高,差异有统计学意义(P<0.05)。结论:前列地尔与甲钴胺片联合应用能够减轻DPN患者的临床症状,改善其神经传导速度,提高临床疗效,且安全性高,无明显不良反应,值得临床推广应用。
Objective: To observe the clinical efficacy and safety of application of alprostadil in combination with mecobalamin in the treatment of diabetic peripheral neuropathy (DPN). Methods: Forty-three patients with DPN who were treated from June 2010 to October 2012 were given intramuscular mecobalamin (500μg.d -1, qd) on the basis of conventional therapy such as blood glucose and blood lipid, while intravenous drip Alprostadil 100μg.d ~ (-1), qd, treatment for 4 weeks. Compare the curative effect before and after treatment and the improvement of nerve conduction function. Results: The DPN patients in 43 cases were markedly effective in 24 cases (55.8%), effective in 14 cases (32.6%) and ineffective in 5 cases (11.6%), with a total effective rate of 88.4% after 4 weeks of treatment. Compared with those before treatment, After the change of nerve conduction velocity (NCV) were significantly increased, the difference was statistically significant (P <0.05). Conclusion: The combination of alprostadil and mecobalamin can alleviate the clinical symptoms, improve the nerve conduction velocity and improve the clinical curative effect of DPN patients, and is safe and has no obvious adverse reactions, which is worthy of clinical application.