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目的 探讨巨噬细胞移动抑制因子(macrophagemigrationinhibitoryfactor ,MIF)在冠状动脉粥样硬化斑块形成中的作用。方法 冠脉造影 (coronaryangiogra phy ,CAG)提示冠脉病变狭窄程度≥ 70 %明确诊断冠心病患者 4 3例为冠心病组 ,CAG冠脉无狭窄的患者 4 3例为正常对照组 ,测定两组间外周血血浆MIF浓度。结果 两组间外周血所测得MIF浓度存在明显差异 ,冠心病组血浆MIF浓度明显小于正常对照组 [(13 70 9± 11 4 95 )ng/mL与 (30 5 2 6±7 84 5 )ng/mL ,P <0 0 1]。结论 冠心病患者血浆MIF水平较正常人明显减低 ,MIF可能参与冠脉粥样硬化的形成过程
Objective To investigate the role of macrophage migration inhibitory factor (MIF) in the formation of coronary atherosclerotic plaque. Methods Coronary angiography (CAG) suggested that the degree of coronary artery stenosis was 70%. Forty-three patients with coronary artery disease were diagnosed as coronary heart disease. Forty-three patients with coronary artery stenosis without coronary artery disease were selected as normal control group. Two groups Between peripheral blood plasma MIF concentrations. Results There was a significant difference in the MIF concentrations measured in the peripheral blood between the two groups. The plasma MIF concentration in CHD group was significantly lower than that in the control group [(13 70 9 ± 11 495) ng / mL vs (30 526 ± 7 84 5) ng / mL, P <0 0 1]. Conclusions Plasma MIF levels in patients with coronary heart disease are significantly lower than those in normal subjects, and MIF may be involved in the formation of coronary atherosclerosis