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目的:探讨肾上腺素联合立止血治疗新生儿肺出血的疗效。方法:将2006年7月~2008年10月期间22例肺出血患儿分为治疗组(12例)和对照组(10例)。对照组诊断肺出血后立即给予气管插管,呼吸机人工通气,1∶10 000肾上腺素按0.3 m l/kg气管内注入;治疗组在应用肾上腺素基础上联合立止血治疗观察其疗效及转归。结果:治疗组患儿的死亡率33.3%,肺出血停止时间平均(5.9±0.3)h,上机时间平均(73.3±5.1)h,对照组患儿的死亡率50.0%,肺出血停止时间平均(8.0±0.2)h,上机时间平均(88.7±6.7)h。与对照组比较治疗组死亡率低,肺出血停止时间及上机时间短,比较有统计学差异(P<0.05)。结论:肾上腺素联合立止血气管内注入可降低肺出血患儿的死亡率,改善肺出血患儿的预后。
Objective: To investigate the curative effect of epinephrine combined with antithrombotic therapy on neonatal pulmonary hemorrhage. Methods: From July 2006 to October 2008, 22 cases of pulmonary hemorrhage were divided into treatment group (12 cases) and control group (10 cases). In the control group, the endotracheal intubation was given immediately after the diagnosis of pulmonary hemorrhage and the ventilator was ventilated. The 1:10 000 epinephrine was injected intratracheally at 0.3 ml / kg. The treatment group was treated with epinephrine combined with rhizome blood to observe the curative effect and outcome . Results: The mortality rate in the treatment group was 33.3%, the mean duration of pulmonary hemorrhage stopped (5.9 ± 0.3) h, the average time on the machine (73.3 ± 5.1) h, the mortality rate in the control group was 50.0% (8.0 ± 0.2) h, the average time on the machine (88.7 ± 6.7) h. Compared with the control group, the treatment group had lower mortality rate, shorter duration of pulmonary hemorrhage and shorter operation time (P <0.05). Conclusion: Epinephrine combined with rhubarb can reduce the mortality of children with pulmonary hemorrhage and improve the prognosis of children with pulmonary hemorrhage.