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自1976年Greenberg首次应用干扰素(IFN)治疗慢性乙型肝炎以来,国内外治疗病例日渐增多,显示出较好疗效。我院自1988年8月以来用IFN治疗慢性乙型肝炎。现就该药对乙型肝炎病毒血清标志物(HBV～M)的影响报告如下。1 病例选择全部病例均为住院的慢性乙型肝炎患者,按随机抽样法将46例分为2组。全部病例病程均超过半年。入院时均有轻至中度消化道症状及乏力、肝功改变。HBSAg、HB_(?)Ag全部为阳性。诊断标准按1984年全国病毒性肝炎会议所定标准。治疗组23例男18例、女5例,慢性活动型肝炎(CAH)
Since 1976, Greenberg first application of interferon (IFN) treatment of chronic hepatitis B, the increasing number of cases at home and abroad, showed good results. In our hospital since August 1988 with IFN treatment of chronic hepatitis B. Now on the drug on hepatitis B virus serum markers (HBV ~ M) the impact is reported as follows. 1 case selection All cases were hospitalized patients with chronic hepatitis B, according to a random sample of 46 cases were divided into two groups. The duration of all cases were more than six months. All patients had mild to moderate gastrointestinal symptoms and fatigue on admission, liver function changes. HBSAg, HB (?) Ag are all positive. Diagnostic criteria by the 1984 National Conference on viral hepatitis set standards. Treatment group, 23 cases of 18 males and 5 females, chronic active hepatitis (CAH)