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鼻咽型未分化癌(UCNT)是一种与流行地域和 EB 病毒有联系的癌肿,可发生于鼻咽以外的部位,如涎腺、胸腺、喉、扁桃腺和肺。作者在2262例扁桃腺鳞癌中,其中1837例为分化较好或分化差的鳞癌,425例为未分化癌,其中18例有鼻咽型未分化癌的组织学特征,均经扁桃腺或转移淋巴结活组织检查确定。选择病例标准为:1.扁桃腺活组织检查有 UCNT组织学特征;2.无鼻咽部疾病;3.组织学切片经同一的组织病理学家检查。18人中的7人行EB 病毒血清学试验,其中4人有 UCNT 血清抗体发现,其他3人仅有 IgG 抗病毒壳抗原滴度的增高。4例有 EB 病毒血清抗体水平升高和UCNT 的组织学表现,鼻咽部正常,其中3例有淋巴结转移,均对放射治疗敏感。18人中的7人有典型的 UCNT 病人的血清 IgG/VCA 的升高。治疗结果突出,10年生存者占77％,3年生存者7.4％,5年生存者60％,明显好于其他鳞癌,平均存活110个月。远处转移至肝、肺和骨髓的发生率高于其他头颈部肿瘤。Krishnamurthy 等提出涎腺恶性淋巴上皮癌的组织学改变与 UCNT 相似。Lanier 等提出 EB
Nasopharyngeal undifferentiated carcinoma (UCNT) is a cancer associated with endemic and Epstein-Barr virus that can occur outside of the nasopharynx, such as the salivary gland, thymus, larynx, tonsil and lungs. Of 2262 cases of squamous cell carcinoma of the tonsils, 1837 cases were well-differentiated or poorly differentiated squamous cell carcinoma, 425 cases were undifferentiated carcinoma, of which 18 cases had histological features of nasopharyngeal undifferentiated carcinoma, were tonsil Or metastatic lymph node biopsy. Select the case criteria are: 1. tonsil biopsy has UCNT histological features; 2. no nasopharyngeal disease; 3. histological sections by the same histopathologist examination. Seven of 18 patients underwent EBV serological tests, of which 4 had UCNT serum antibodies and the other 3 only had IgG titer increased. In 4 cases, the serum levels of Epstein-Barr virus (EBV) were elevated and the histological features of UCNT were normal. The nasopharynx was normal, and 3 cases had lymph node metastasis, all of which were sensitive to radiotherapy. Seven of 18 patients had elevated serum IgG / VCA in a typical UCNT patient. Outstanding treatment results, 77% of 10-year survival, 7.4% of 3-year survival, 60% of 5-year survival was significantly better than other squamous cell carcinoma, the average survival of 110 months. The distant metastasis to the liver, lung and bone marrow incidence is higher than other head and neck cancer. Krishnamurthy et al proposed histological changes of salivary gland malignant lymphoid epithelial carcinoma similar to UCNT. Lanier et al. Propose EB