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目的探讨良性转移性平滑肌瘤(BML)的临床病理特征、诊断与鉴别诊断。方法回顾性分析6例BML患者的临床资料和组织病理学特点,对肿瘤组织进行光镜观察及免疫组化研究。结果6例BML均为女性,平均50.2岁。5例子宫平滑肌瘤术后7～18年发生转移,其中1例同时发现原发灶和转移灶。肺转移5例,其中1例伴有腰椎转移,另1例为腹腔淋巴结转移,复查子宫手术后病理切片证实为良性平滑肌瘤,肺、淋巴结及腰椎肿瘤组织形态类似于子宫平滑肌瘤,细胞无异型,未找到核分裂象。免疫组化染色证实为平滑肌源性,雌、孕激素受体(+)。结论BML是一种罕见的发生于有子宫平滑肌瘤手术史的女性,肺是主要转移部位,激素依赖性。该病变病程缓慢,手术切除是主要的治疗手段。
Objective To investigate the clinicopathological features, diagnosis and differential diagnosis of benign metastatic leiomyomata (BML). Methods The clinical data and histopathological features of 6 BML patients were retrospectively analyzed. The tumor tissues were observed by light microscopy and immunohistochemistry. Results 6 cases of BML were female, with an average of 50.2 years old. 5 cases of uterine leiomyoma 7 to 18 years after the transfer occurred, including 1 case of both primary and metastatic lesions. 5 cases of lung metastasis, including 1 case of lumbar metastasis, and the other 1 case of abdominal lymph node metastasis, pathological examination confirmed uterine pathology confirmed benign leiomyoma, lung, lymph node and lumbar spine tumor morphology similar to uterine leiomyoma, cells No abnormal, did not find mitotic figures. Immunohistochemistry confirmed smooth muscle-derived, estrogen and progesterone receptors (+). Conclusions BML is a rare occurrence in women with a history of uterine leiomyoma surgery. The lungs are the major metastatic sites and are hormone-dependent. The slow course of the disease, surgical resection is the main treatment.