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目的:探讨胰腺嗜酸性神经内分泌癌的临床病理特点、诊治和预后。方法:对1例胰腺嗜酸性内分泌癌从临床、光镜、免疫组化观察和结合文献分析。结果:病变发展快,转移早。癌细胞中等大小一致、呈巢状、菊形团样排列,浸润性生长,边界不清,胞质嗜酸性,淋巴结内癌转移。Syn、NSE、CgA和CK+阳性。结论:胰腺嗜酸性内分泌癌发病机理不清晰;肿瘤病理免疫组化是目前确诊的唯一手段;治疗困难,姑息性手术治疗是首选;预后极差。
Objective: To investigate the clinicopathological features, diagnosis, treatment and prognosis of eosinophilic neuroendocrine carcinoma of the pancreas. Methods: One case of eosinophilic endocrine pancreas was analyzed by clinical, light microscope, immunohistochemistry and combined literature. Results: The lesions developed rapidly and metastasized earlier. The same size of cancer cells were nested, daisy-like arrangement, infiltration of growth, the boundary is unclear, eosinophilic cytoplasm, lymph node metastasis. Syn, NSE, CgA and CK + positive. Conclusions: The pathogenesis of eosinophilic endocrine neoplasm of the pancreas is not clear. The pathological immunohistochemistry of the tumor is the only way to confirm the diagnosis. The treatment is difficult. Palliative surgery is the first choice and the prognosis is very poor.