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目的与方法：应用硝酸根还原法测定新生儿休克时血浆一氧化氮（ＮＯ） 的含量变化，了解ＮＯ 在新生儿休克发生的病理生理意义，为今后治疗新生儿休克提供帮助。结果：与对照组相比，休克组血浆ＮＯ 水平明显升高。并且，随着休克程度的加重血浆ＮＯ 水平也随之增高。结论：新生儿休克，特别是中、重度休克时血压下降导致血循环与ＮＯ 的大量产生释放有关。降低血循环中ＮＯ 的合成和释放，可能是临床治疗新生儿休克的一个重要渠道。
Aims and Methods: Nitric oxide reduction method was used to determine the change of plasma nitric oxide (NO) level during neonatal shock, and to understand the pathophysiological significance of NO in neonatal shock and to provide help for the treatment of neonatal shock in the future. Results: Compared with the control group, plasma NO levels in shock group were significantly increased. And, with the aggravation of the degree of shock plasma NO levels also increased. CONCLUSIONS: Neonatal shock, especially in moderate and severe shock, leads to a decrease in blood pressure associated with the release and release of large amounts of NO. Reduce the synthesis and release of NO in the blood circulation may be an important channel for the clinical treatment of neonatal shock.