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目的 :研究广西藤茶中双氢杨梅树皮素的保肝作用。方法 :采用四氯化碳、D -半乳糖胺和异硫氰酸萘酯致小鼠急性肝损伤模型 ,观察双氢杨梅树皮素对肝损伤的保护作用 ;采用小鼠单核巨噬细胞吞噬作用和免疫低下小鼠溶血素生成试验 ,观察双氢杨梅树皮素的免疫增强作用。结果 :双氢杨梅树皮素能明显降低四氯化碳、D -半乳糖胺和异硫氰酸萘酯致小鼠急性肝损伤模型血清中ALT、AST活性和T -BIL含量 ,减轻肝组织的变性和坏死 ;并提高单核巨噬细胞吞噬功能和溶血素含量。结论 :双氢杨梅树皮素具有保肝降酶退黄 ,提高免疫功能作用。
Objective : To study the hepatoprotective effects of dihydromyricetin in Guangxi vine tea. METHODS: The acute hepatic injury model induced by carbon tetrachloride, D-galactosamine and naphthyl isothiocyanate was used to observe the protective effect of dihydromyricetin on hepatic injury. Mononuclear macrophage cells were used in mice. Phagocytosis and immunocompromised mouse hemolysin production tests were performed to observe the immunopotentiating effects of dihydromyricetin. RESULTS: Dihydromyricetrin could significantly reduce the serum ALT, AST and T-BIL levels in mice with acute hepatic injury induced by carbon tetrachloride, D-galactosamine and naphthyl isothiocyanate, and reduce the liver tissue. The degeneration and necrosis; and increased mononuclear macrophage phagocytosis and hemolysin content. Conclusion : Dihydromyricetin has the effect of protecting the liver and reducing enzyme yellowing and improving immune function.