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目的通过检测胃癌组织表皮生长因子受体的表达，初步探讨其与胃癌的关系及临床意义。方法采用免疫组化ＡＢＣ法测定了７０例胃切除标本组织内表皮生长因子受体（ＥＧＦＲ）的表达，其中包括正常胃粘膜标本１８例，胃癌５２例。结果正常胃粘膜组织无ＥＧＦＲ表达，肿瘤组织有２３例（４４．２３％）呈阳性；在肿瘤组织，ＥＧＦＲ阳性率在有淋巴结转移者为６５．３９％，显著高于无转移者（２３．０８％）；弥漫性胃癌组织ＥＧＦＲ阳性率为６６．６７％，高于肠型（２５％）。胃癌组织ＥＧＦＲ表达阳性者其生存率也显著低于阴性组。结论胃癌组织ＥＧＦＲ的监测可以作为了解肿瘤生物学行为及患者预后的一个指标。
Objective To explore the relationship between gastric epithelial growth factor receptor expression and gastric cancer and its clinical significance. Methods Immunohistochemical ABC method was used to measure the expression of epidermal growth factor receptor (EGFR) in 70 cases of gastric resection specimens, including 18 cases of normal gastric mucosa and 52 cases of gastric cancer. Results There was no EGFR expression in normal gastric mucosa, and there were 23 cases (44.23%) positive in tumor tissue. In tumor tissue, the positive rate of EGFR in lymph node metastasis was 65.39%, which was significantly higher than those without metastasis (23. 08%); diffuse gastric cancer EGFR positive rate was 66.67%, higher than the intestinal type (25%). The positive rate of EGFR expression in gastric cancer was also significantly lower than that in the negative group. Conclusion The monitoring of EGFR in gastric cancer can be used as an indicator to understand the biological behavior of tumors and prognosis of patients.