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N-苄氧羰基-L-谷氨酸-α-甲酯(1)按 Barton 等氧化脱羧可得2。随即用氢化钠行γ-消除,得中间产物3。3可氢解为1-氨基环丙烷-1-羧酸甲酯以合成肽,亦可用氢氧化
N-Benzyloxycarbonyl-L-glutamic acid-α-methyl ester (1) Oxidative decarboxylation according to Barton et al. Then with sodium hydride line γ-elimination, intermediate 3.3 can be hydrogenolysis of 1-aminocyclopropane-1-carboxylic acid methyl ester for the synthesis of peptides can also be used hydroxide