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已知甲状旁腺功能减退(甲旁减)患者可出现多种神经精神症状,其中巴金森氏征群是常见并发症之一,临床予以左旋多巴治疗无效,而多经钙剂及维生素D治疗后症状明显缓解以至消失,说明低血钙是产生其症状的重要动因,但详细机理不明。本研究采用去除甲状旁腺(PTX)的低血钙大鼠为模型,探讨低血钙影响中枢神经系统功能们作用机理。实验采用Wistar大鼠,腹腔麻醉后切开颅部暴露双侧甲状旁腺并用电烫去除。PTX组术后饲以低钙饲料(0.04％Ca)一个月,对照组及老龄组(20周龄)用普通饲料(1.04％Ca)喂养。钙测定用原子
Known hypoparathyroidism (hypoparathyroidism) patients may appear a variety of neuropsychiatric symptoms, including Parkinson’s syndrome is one of the common complication, clinically levodopa treatment ineffective, and more by calcium and vitamin D Symptoms after treatment significantly alleviate or even disappear, indicating that hypocalcemia is an important cause of their symptoms, but the detailed mechanism is unknown. In this study, hypocalcemic rats with hypothyroidism (PTX) were used as models to investigate the mechanism of hypocalcemia affecting central nervous system function. Wistar rats were used in the experiment. The cadaveric craniot was exposed after peritoneal anesthesia and was removed by electroporation. The PTX group was fed with low calcium diet (0.04% Ca) for one month postoperatively. The control group and the aged group (20 weeks old) were fed with normal diet (1.04% Ca). Calcium determination of atoms