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目的探讨胆道感染及肝胆肿瘤患者外周血、胆汁中内皮素(ET)及降钙素基因相关肽(CGRP)浓度变化的意义。方法采用放射免疫分析检测120例肝胆道感染和肝胆肿瘤患者外周血、胆汁中ET、CGRP的浓度。结果肝胆感染患者外周血中ET、CGRP的质量浓度分别为(56.85±16.54)pg/ml和(96.34±20.05)pg/ml;肝胆肿瘤组的ET、CGRP的值分别为(107.35±14.44)pg/ml和(36.37±14.79)pg/ml,与对照组ET及CGRP的值(42.88±11.96)pg/ml、(24.04±17.45)pg/ml比较差异有显著性(P<0.01),肝胆道感染及肿瘤患者胆汁中ET值为(61.36±13.72)pg/ml、(71.38±16.27)pg/ml,CGRP值为(250.07±43.19)pg/ml、(198.71±35.68)pg/ml,与对照组的ET、CGRP值[(18.56±7.40)pg/ml,(165.36±28.07)pg/ml]比较差异有显著性(P<0.01)。结论ET、CGRP参与了肝胆感染及肝胆肿瘤疾病发病过程,其作用机制尚需深入研究。
Objective To investigate the significance of changes of endothelin (ET) and calcitonin gene related peptide (CGRP) in peripheral blood and bile of patients with biliary tract infection and hepatobiliary tumor. Methods Radioimmunoassay was used to detect the concentrations of ET and CGRP in peripheral blood and bile of 120 patients with hepatobiliary tract infection and hepatobiliary tumor. Results The concentrations of ET and CGRP in peripheral blood of patients with hepatobiliary infection were (56.85 ± 16.54) pg / ml and (96.34 ± 20.05) pg / ml, respectively. The values of ET and CGRP in hepatobiliary tumor were (107.35 ± 14.44) pg / (36.37 ± 14.79) pg / ml, which was significantly higher than that of the control group (42.88 ± 11.96) pg / ml and (24.04 ± 17.45) pg / ml respectively The values of ET in bile of infected and tumor patients were (61.36 ± 13.72) pg / ml, (71.38 ± 16.27) pg / ml and CGRP values were (250.07 ± 43.19) pg / ml and (198.71 ± 35.68) pg / The ET and CGRP values in the group [(18.56 ± 7.40) pg / ml, (165.36 ± 28.07) pg / ml] were significantly different (P <0.01). Conclusions ET and CGRP are involved in the pathogenesis of hepatobiliary disease and hepatobiliary tumor. The mechanism of action is still to be further studied.