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本文用动态心电图观察了高血压病左室肥厚患者室性心律失常的发生情况及血管紧张素转换酶抑制剂卡托普利与钙通道阻滞剂硝苯地平(硝苯吡啶)对血浆儿茶酚胺活性、红细胞内离子(K~+、Na~+、Ca~(2+)、Mg~(2+))含量、左室重量与厚度及室性心律失常的影响。结果表明,卡托普利及硝苯地平均能显著减轻高血压病左室肥厚患者左室重量与厚度,纠正细胞内离子代谢失衡,在逆转心肌肥厚的同时,显著减低了高血压病左室肥厚患者室性心律失常的发生。卡托普利可显著减低血浆儿茶酚胺活性,硝苯地平则使血浆儿茶酚胺活性升高。
In this paper, we observed the occurrence of ventricular arrhythmia in hypertensive patients with left ventricular hypertrophy by dynamic electrocardiogram and the effects of captopril, an angiotensin converting enzyme inhibitor, and calcium channel blocker nifedipine on plasma catecholamine activity (K ~ +, Na ~ +, Ca ~ (2 +), Mg ~ (2+)), left ventricular weight and thickness, and ventricular arrhythmia were measured. The results showed that both captopril and nifedipine could significantly reduce the left ventricular weight and thickness in patients with hypertensive left ventricular hypertrophy and correct intracellular ion metabolism imbalance, while reversing cardiac hypertrophy and significantly reducing left ventricular hypertrophy Hypertrophic patients with ventricular arrhythmias. Captopril significantly reduced plasma catecholaminergic activity while nifedipine increased plasma catecholaminergic activity.