近年来 ,细菌耐药趋势日趋严峻 ,成为医学界倍受关注的问题。具有重要临床意义的耐药菌有青霉素耐药肺炎链球菌、甲氧西林耐药葡萄球菌、万古霉素耐药肠球菌、β内酰胺类抗生素耐药革兰阴性杆菌。上述耐药菌不仅呈逐年增多趋势 ,且常为多重耐药菌 ,致使该类菌所致感染的治疗成 In recent years, the trend of bacterial resistance is becoming more and more serious, which has become a major concern in the medical field. There are important clinical significance of resistant bacteria penicillin-resistant Streptococcus pneumoniae, methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus, β-lactam antibiotic-resistant Gram-negative bacilli. The resistant bacteria not only showed an increasing trend year by year, and often multi-resistant bacteria, resulting in the treatment of these bacteria into