目的检测胃癌患者血清血管内皮生长因子(vascular endothelial growth factor,VEGF)表达水平并探讨其临床意义。方法采用酶联免疫吸附技术检测52例胃癌患者及27名健康人血清VEGF水平。结果胃癌患者血清VEGF水平[(293.32±164.35)ng/L]明显高于对照组[(116.26±47.15)ng/L](P<0.05);血清VEGF水平与肿瘤大小、临床分期等有关,与年龄、性别、组织分化程度等因素无关。结论VEGF在胃癌发生、发展过程中起重要作用,检测血清VEGF水平对胃癌的诊断、治疗判断有重要意义。 Objective To detect the expression of vascular endothelial growth factor (VEGF) in gastric cancer patients and to explore its clinical significance. Methods Serum VEGF levels were measured by enzyme-linked immunosorbent assay in 52 patients with gastric cancer and 27 healthy individuals. Results Serum VEGF level in gastric cancer patients was significantly higher than that in the control group [(293.32 ± 164.35) ng / L [(116.26 ± 47.15) ng / L] (P <0.05). Serum VEGF levels were correlated with tumor size and clinical stage Age, gender, degree of differentiation and other factors have nothing to do. Conclusion VEGF plays an important role in the occurrence and development of gastric cancer. The detection of serum VEGF levels is of great significance in the diagnosis and treatment of gastric cancer.