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巨噬细胞移动抑制因子(MIF)是一种重要的前炎症因子,主要作用为抑制巨噬细胞的游走移动,促进巨噬细胞在炎症局部浸润、聚集、增生、活化,增强其黏附、吞噬作用,还能促进多种炎性细胞因子的生成。MIF广泛参与机体多种生理及病理生理学反应,包括炎性反应、肿瘤生成和皮肤创伤修复等。MIF在病毒性心肌炎发病机制中起重要作用。近年来,随着克隆MIFcDNA的成功及其结构的阐明,MIF的特殊生物功能及其在不同炎症性疾病中的重要作用已日益为人们所重视。
Macrophage migration inhibitory factor (MIF) is an important proinflammatory cytokine which plays an important role in inhibiting the migration of macrophages and promoting the infiltration, aggregation, proliferation and activation of macrophages in the inflammatory area, enhancing their adhesion and phagocytosis Role, but also promote the formation of a variety of inflammatory cytokines. MIF is widely involved in many physiological and pathophysiological reactions in the body, including inflammatory reactions, tumorigenesis and skin wound repair. MIF plays an important role in the pathogenesis of viral myocarditis. In recent years, with the successful cloning of MIF cDNA and its elucidation of the structure, the special biological function of MIF and its important role in different inflammatory diseases have been paid more and more attention.