人附睾蛋白4在子宫内膜癌患者血清中的表达及其与CA125联合检测的临床价值

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目的:通过检测正常子宫内膜、子宫内膜不典型增生、子宫内膜癌患者血清HE4,CA125表达情况,探讨HE4、CA125对子宫内膜癌诊断的临床意义。方法:采用化学发光微粒子免疫分析法(CMIA)检测15例子宫良性病变患者、10例子宫内膜不典型增生患者、40例子宫内膜癌患者血清中HE4和CA125的表达情况。结果:(1)HE4,CA125在子宫内膜癌患者血清中高表达。(2)血清HE4,CA125水平与子宫内膜癌患者的年龄、组织分级及病理类型无关(P〉0.05);而与手术-病理分期、肌层浸润深度及淋巴结转移密切相
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