慢性粒细胞白血病(CML)是一种粒细胞增殖性疾患,临床可分三期。起始期的细胞遗传学特征为,具有9q34与22q13相互易位形成的Ph染色体。c-abl和bcr基因分别位于9号和22号染色体长臂的断裂点附近。基本上具有t(9;22)的CML患者都存在这两个基因的相互易位。当CML发展至急变期(CML-BP)时,就出现另一些细胞遗传学畸变。其中最为常见的是Ph染色体复制和 Chronic myelogenous leukemia (CML) is a granulocyte proliferative disorder that can be clinically divided into three phases. The cytogenetic feature of the initiating phase is that Ph has the reciprocal translocation formed between 9q34 and 22q13. The c-abl and bcr genes are located near the breakpoints of the long arms of chromosomes 9 and 22, respectively. The reciprocal translocation of these two genes is present in CML patients with essentially t(9;22). When CML develops to CML-BP, there are other cytogenetic aberrations. The most common of these is Ph chromosome replication and