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用免疫荧光染色和流式细胞术观察p140的表达,并用移植肾穿刺活检证实排斥反应。结果表明,P140在肾移植患者淋巴细胞亚群及活化T细胞有弱表达,存在排斥反应时表达增强。提示p140为一种新的移植抗原诱导的T细胞活化分子;p140在肾移植患者排斥反应时表达增强,有可能成为特异的判别指标。
The expression of p140 was observed by immunofluorescence staining and flow cytometry, and rejection was confirmed by transplanted renal biopsy. The results showed that there was weak expression of P140 in lymphocyte subsets and activated T cells in renal transplant recipients, and the expression of P140 was enhanced in the presence of rejection. Suggesting that p140 is a new T cell activation molecule induced by transplantation antigen; p140 expression in renal transplant recipients increased rejection may be a specific discriminant.