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目的探讨灯盏花素注射液联合血管紧张素转换酶抑制剂(ACEI)依那普利治疗糖尿病早期肾病的临床效果。方法 2006年10月2009年12月,将59例临床确诊2型糖尿病早期肾病的患者随机分为治疗组(n=30)与对照组(n=29)。对照组在基本治疗的基础上应用依那普利,治疗组在基本治疗的基础上联合应用依那普利和灯盏花素注射液,疗程均为3周。观察治疗前后两组患者24 h尿微量白蛋白排泄率(UAER)、全血黏度、血浆黏度、甘油三酯(TG)、尿素氮(BUN)、血肌酐(SCr)的变化。结果两组患者治疗前后自身对比,24 h UAER均有明显下降(P<0.05);治疗组UAER下降较对照组更为明显(P<0.05)。结论 ACEI联合灯盏花素,其降低24 h UAER疗效优于单纯ACEI疗效,还可有效降低全血黏度和血浆黏度,降低纤维蛋白原含量,改善患者血液流变性。
Objective To investigate the clinical efficacy of breviscapine injection combined with angiotensin converting enzyme inhibitor (ACE) enalapril in the treatment of diabetic nephropathy. Methods From October 2006 to December 2009, 59 patients with clinically diagnosed type 2 diabetic nephropathy were randomly divided into treatment group (n = 30) and control group (n = 29). The control group received enalapril on the basis of the basic treatment. The treatment group was given enalapril and breviscapine injection on the basis of the basic treatment for 3 weeks. The changes of 24 h urinary albumin excretion rate (UAER), whole blood viscosity, plasma viscosity, triglyceride (TG), blood urea nitrogen (BUN) and serum creatinine (SCr) were observed before and after treatment. Results Compared with the control group, the UAER in the two groups were significantly decreased 24 h after treatment (P <0.05). Conclusions The combination of ACEI and breviscapine can reduce the effect of UAER for 24 h on ACEI. It can also reduce whole blood viscosity and plasma viscosity, lower the content of fibrinogen, and improve the hemorrheology.