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近年来通过对缺血性脑血管病的病理生理机制进行了大量的研究,发现血浆同型半胱氨酸(Hcy)及纤溶酶原激活物抑制剂-1(PAI-1)水平升高同缺血性脑血管病(ICVD)的发生存在显著相关性。本文就Hcy和PAI-1各自的特性、影响因素、同ICVD的关系及致ICVD的机理等几方面的研究近况进行了综述。
In recent years through a large number of pathophysiological mechanisms of ischemic cerebrovascular disease conducted a large number of studies found that plasma homocysteine (Hcy) and plasminogen activator inhibitor-1 (PAI-1) levels increased The incidence of ischemic cerebrovascular disease (ICVD) was significantly correlated. This review summarizes recent developments in the properties of Hcy and PAI-1, their influencing factors, the relationship with ICVD and the mechanism of ICVD.