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目的探讨胃肠癌患者血清性激素水平及其临床意义。方法采用放射免疫法,测定122例胃癌患者血清黄体生成素(LH)、卵泡刺激素(FSH)、催乳素(PRL)、睾酮(T)及雌二醇(E2)水平。结果胃癌患者E2、T水平与正常对照组比较显著下降(P<0.05),女性患者E2水平下降更为明显(P<0.01);PLR、LH及FSH水平男性患者与对照组比较,差异无统计学意义(P>0.05),女性患者PRL水平显著高于对照组(P<0.01)。E2、T水平随胃癌分期表现为I期>II期>III期>IV期,I期较III期、IV期差异有统计学意义(P<0.05)。结论胃癌患者血清性激素水平变化检测结果可指导判断病情与发展预后。
Objective To investigate the serum levels of sex hormone in patients with gastrointestinal cancer and its clinical significance. Methods The serum levels of luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin (PRL), testosterone (T) and estradiol (E2) in 122 patients with gastric cancer were measured by radioimmunoassay. Results The levels of E2 and T in patients with gastric cancer decreased significantly (P <0.05), and the levels of E2 in women patients decreased more significantly (P <0.01). There was no statistical difference between male and female patients with PLR, LH and FSH levels (P> 0.05). The PRL level in female patients was significantly higher than that in control group (P <0.01). The levels of E2 and T in gastric cancer showed stage I> stage II> stage III> stage IV, stage I compared with stages III and IV (P <0.05). Conclusion The results of serum hormone test in patients with gastric cancer can guide the judgment of prognosis and prognosis.