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作者对既往9年间,61例初次复发的急性髓性白血病(AML)的治疗结果作回顾性分析。复发时处于维持治疗中42例(68.8%)。38例复发后采用与最初化疗方案相同的方案作再诱导,31例取得CR,23例采用改变方案再诱导4例取得CR,总缓解率为57.4%(35/61例)。其余26例中15例骨髓抑制未CR,11例(18%)在治疗中及治疗后一周内死亡,死亡原因为出血4例。感染5例。肝功能衰竭1例及其他1例。再次缓解率(CR_2)分析:与性别无差异;<50岁
The authors retrospectively analyzed the results of the treatment of 61 cases of relapsed acute myeloid leukemia (AML) during the past 9 years. At the time of recurrence, 42 patients (68.8%) were in maintenance therapy. After relapse, 38 patients were re-induced with the same regimen as the original chemotherapy regimen. CR was obtained in 31 cases, and CR was obtained in 23 cases and 4 cases were re-inducted with CR. The total remission rate was 57.4% (35/61 cases). Of the remaining 26 cases, 15 cases of myelosuppression were not CR, and 11 cases (18%) died during the treatment and one week after treatment. The cause of death was bleeding in 4 cases. Infection in 5 cases. Liver failure in 1 case and 1 other case. Re-remission rate (CR_2) analysis: no difference with gender; <50 years old