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目的:观察采用玻璃化冷冻技术行全胚胎冷冻后解冻移植患者的临床结局,并与同期新鲜周期移植患者相比较,探讨玻璃化冷冻技术在全胚胎冷冻并行复苏移植中的应用价值。方法:全胚胎冷冻组为体外受精(IVF)未移植患者40个周期,新鲜周期组为同期体外受精及胚胎移植(IVF-ET)患者300例,对2组的平均移植胚胎数、优质胚胎数、子宫内膜厚度、雌二醇(E2)水平、临床妊娠率进行比较。结果:2组之间在平均移植胚胎数、优质胚胎数、子宫内膜厚度方面的差异均无统计学意义(P>0.05);新鲜周期组的E2水平明显高于全胚胎冷冻组(P<0.05),临床妊娠率明显低于全胚胎冷冻组(P<0.05)。结论:玻璃化冷冻技术是一种简便、可靠、高效的胚胎冷冻技术;对于符合要求的患者,全胚胎冷冻并适时行冻胚移植是可行的胚胎移植策略,值得临床深入研究和推广。
OBJECTIVE: To observe the clinical outcome of vitrification in patients undergoing total embryo thawing after thawing and compared with fresh-cycle transplant patients in the same period. Methods: The whole embryo freezing group was 40 cycles of IVF transplantation. The fresh cycle group consisted of 300 cases of in vitro fertilization and embryo transfer (IVF-ET). The average number of embryos transferred, the number of high quality embryos , Endometrial thickness, estradiol (E2) level, clinical pregnancy rate were compared. Results: There was no significant difference in the average number of embryos transferred, the number of high quality embryos and the thickness of endometrium between the two groups (P> 0.05). The E2 level in the fresh cycle group was significantly higher than that in the whole embryo frozen group (P < 0.05). The clinical pregnancy rate was significantly lower than that of the whole embryo freezing group (P <0.05). Conclusion: Vitrification is a simple, reliable and efficient embryo freezing technique. It is a feasible embryo transfer strategy to meet the requirements of patients with full embryo freezing and frozen embryo transfer timely. It deserves clinical further research and promotion.