论文部分内容阅读
目的探讨米胚粉饮食干预对Ⅱ型糖尿病模型SD雄性大鼠的影响,为防治Ⅱ型糖尿病的相关并发症提供科学依据。方法 102只SD雄性大鼠随机分为Ⅱ型糖尿病模型组和正常对照组,前者给予高脂高糖饲料和小剂量STZ后,再随机分为模型组、阳性对照组及米胚粉低、中、高剂量组,分别给予普通饲料、普通饲料+500mg/kg二甲双胍溶液灌胃、2.5%、10%、40%米胚粉饲料,正常对照组给予普通饲料。饮食干预4周后,计算各组大鼠死亡率,并检测血清及肝脏抗氧化指标(SOD、MDA、GSH-PX)和血脂指标(TG、CHO、LDL-C)。结果高剂量组无死亡发生,高剂量组与模型组相比较,血清与肝脏中SOD显著增加[分别为(44.81±6.17)、(150.36±24.11)U/ml](P<0.05),MDA显著降低[分别为(7.53±1.84)、(7.07±1.13)U/ml](P<0.05),且血清CHO与LDL-C明显降低[分别为(2.57±0.41)、(1.04±0.47)mmol/L](P<0.05)。结论米胚粉对Ⅱ型糖尿病大鼠具有降血脂、改善氧化损伤、降低死亡率的作用。
Objective To investigate the effects of rice bran meal diet intervention on SD male rats with type Ⅱ diabetes mellitus, and to provide a scientific basis for the prevention and treatment of complications related to type Ⅱ diabetes mellitus. Methods 102 male Sprague-Dawley rats were randomly divided into two groups: model group and normal control group. The former was given high-fat and high-sugar diet and low-dose STZ, then randomly divided into model group, positive control group and low- , High dose group were given normal feed, normal feed + 500mg / kg metformin solution gavage, 2.5%, 10%, 40% rice embryo meal feed, the normal control group given ordinary feed. After 4 weeks of diet intervention, the mortality of rats in each group was calculated, and the serum and liver antioxidant indexes (SOD, MDA, GSH-PX) and blood lipid (TG, CHO, LDL-C) were measured. Results There was no death in the high-dose group. Compared with the model group, the SOD level in the high-dose and high-dose groups was significantly increased (44.81 ± 6.17 and 150.36 ± 24.11 U / ml, respectively, P <0.05) (2.57 ± 0.41) and (1.04 ± 0.47) mmol / L, respectively, compared with the control group (7.53 ± 1.84 and 7.07 ± 1.13 U / ml, P < L] (P <0.05). Conclusion The effect of rice germ powder on reducing blood fat, improving the oxidative damage and decreasing the mortality of type 2 diabetic rats.