论文部分内容阅读
目的研究体内核转录因子NF-κBp65和细胞间黏附分子-1(ICAM-1)在口腔鳞状细胞癌组织中的表达及意义。方法采用免疫组织化学染色法检测30例口腔鳞状细胞癌组织和10例正常成年人口腔黏膜组织的NF-κBp65蛋白及ICAM-1的表达水平。结果(1)口腔鳞状细胞癌组织中NF-κBp65蛋白和ICAM-1表达水平均较正常口腔黏膜组织增强(P<0.001);(2)NF-κBp65蛋白表达和ICAM-1表达呈正相关(r=0.864,P=0.000)。结论NF-κBp65的激活导致口腔鳞状细胞癌患者体内ICAM-1表达增强,促进了机体自身细胞免疫抗肿瘤的作用,可能成为口腔鳞状细胞癌治疗的一个新靶点。
Objective To study the expression and significance of nuclear factor-κBp65 and intercellular adhesion molecule-1 (ICAM-1) in oral squamous cell carcinoma tissue. Methods The expression of NF-κBp65 protein and ICAM-1 in oral mucosa of 30 cases of oral squamous cell carcinoma and 10 cases of normal adults were detected by immunohistochemical staining. Results (1) The expression of NF-κBp65 protein and ICAM-1 in oral squamous cell carcinoma tissues were significantly higher than those in normal oral mucosa (P <0.001). (2) The expression of NF-κBp65 was positively correlated with the expression of ICAM- r = 0.864, P = 0.000). CONCLUSION: The activation of NF-κBp65 leads to the enhancement of ICAM-1 expression in oral squamous cell carcinoma and enhances the anti-tumor effect of its own cellular immunity, which may be a new target for the treatment of oral squamous cell carcinoma.