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目的研究用自制RBC药盒制备的99mTcRBC人体内稳定性和内照射辐射吸收剂量。方法4名健康志愿者,分别取肘静脉血1ml,用自制的RBC药盒进行放射性锝标记,每人注射481～555MBq,给药后5min,1,2.5,4,8和24h进行全身显像,测定99mTcRBC在人体内的生物分布;计算各器官在各时间点的放射性占注入量的百分数(%ID);两种方法绘制各脏器时间放射性计数曲线,计算各脏器的滞留时间,用MIRDOSE3.0软件计算出各受照器官的内照射辐射剂量。结果99mTcRBC在人体内较稳定,血池及大血管于给药后5min至8h均可清晰显影;人体内照射辐射吸收剂量估算结果与文献值相近,按一次给药555MBq计算,各器官的吸收剂量均低于50mGy。结论用本实验室自制RBC药盒制备的99mTcRBC体内稳定性好,内照射辐射吸收剂量符合要求。
OBJECTIVE: To study the stability of human 99mTcRBC human in vivo prepared with homemade RBC kit and the dose absorbed by internal radiation. Methods Four healthy volunteers were divided into 1 ml intravenous elbow vein and labeled with radioactive technetium using a homemade RBC kit. 481-555 MBq were injected per patient, and the whole body was performed at 1, 2.5, 4, 8 and 24 hours after administration , To determine the biodistribution of 99mTcRBC in the human body; calculate the percentage of radioactivity (% ID) of each organ in each time point; two methods to draw the radioactivity count curve of each organ, calculate the residence time of each organ with The MIRDOSE 3.0 software calculates the internal radiation dose for each illuminated organ. Results 99mTcRBC was stable in human. The blood pool and large blood vessel could be clearly developed 5min to 8h after administration. The estimated dose absorbed by human body was similar to the reference value. According to the single dose of 555MBq, the absorbed dose of each organ All below 50 mGy. Conclusion The 99mTcRBC prepared by our laboratory homemade RBC kit has good stability in vivo and the absorbed dose of internal irradiation meets the requirements.