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糖尿病的代谢改变介导调亡调节基因在肾小管上皮细胞内的表达，而促使细胞凋亡。这可能是糖尿病的肾病发病机理因素之一。在暴露于高葡萄糖环境或糖尿病的肾脏中的肾近曲小管上皮细胞内凋亡调节基因的表达
Metabolic changes in diabetes mediate the expression of apoptosis-regulating genes in renal tubular epithelial cells, leading to apoptosis. This may be one of the pathogenesis of diabetic nephropathy. Expression of apoptosis-regulating genes in proximal tubular epithelial cells in kidneys exposed to high glucose or diabetes