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二硫化碳为一亲血管、神经性毒物,因其在工农业生产上日益广泛的应用,早在十九世纪初即有许多关于二硫化碳严重中毒的报告。其中眼部检查之早期报告提出有球后视神经炎,中毒性弱视等改变。一九三一年,McDonald等曾提出瞳孔对光反应减弱和生理盲点扩大是CS_2中毒在眼科最重要的症状;一九六七年S.Goto(日本)发现接触CS_2能引起视网膜微动脉瘤;近年来国内保定化纤厂对260名人造丝企业接触CS_2工人
Carbon disulfide is a pro-angiogenic, neurotoxic agent that has been widely reported as early as the early nineteenth century for severe poisoning of carbon disulfide because of its increasingly widespread use in industrial and agricultural production. One of the earliest reports of eye exams proposed retrobulbar optic neuritis, toxic amblyopia and other changes. In 1931, McDonald et al. Proposed that diminished pupil light response and physiological blind spot enlargement were the most important symptoms of CS2 poisoning in ophthalmology. In 1967, S. Goto (Japan) found that exposure to CS_2 caused retinal micro-aneurysms; In recent years, domestic Baoding Chemical Fiber Factory 260 CSR workers exposed CS_2 workers