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目的通过对山西省吕梁地区50岁以上农村老年男性免费健康体检时血清总前列腺特异性抗原(TPSA)浓度水平的检测,研究是否有必要在常规健康体检时进行TPSA筛查。方法于2011年6月-2013年6月山西省吕梁地区50岁以上农村老年人免费健康体检时,按照分层、随机整群抽样的原则,在周边汾阳市、孝义市、岚县、石楼县、文水县5县市共10乡镇中抽取177名男性,清晨空腹血液检测TPSA浓度。并以年龄分为4组(50~59岁、60~69岁、70~79岁、≥80岁),分析TPSA水平分布情况异常发生率。结果 TPSA浓度超过正常值者6例(4.31~5.08ng/ml),TPSA>4ng/ml的发生率约3.39%,TPSA浓度与年龄未见显著相关(r=0.141,P=0.061)。结论山西省吕梁地区50岁以上农村健康老年男性TPSA增高的发生率较高,有必要在常规体检中进行TPSA筛查,是否作为最终的结论还需要进一步的大样本研究。
Objective To test the level of serum total prostate-specific antigen (TPSA) during free physical examination in rural elderly men over 50 in Luliang, Shanxi Province to investigate if it is necessary to conduct TPSA screening during routine physical examination. Methods According to the principle of stratified and random cluster sampling in the free health check-ups of rural residents over 50 years old in Luliang, Shanxi Province from June 2011 to June 2013, Fenyang City, Xiaoyi City, Lan County, Shilou County, Wenshui County, 5 counties and cities in a total of 177 townships in 177 men, fasting blood TPSA concentration. The patients were divided into 4 groups (50-59 years old, 60-69 years old, 70-79 years old, ≥80 years old). The incidence of abnormal TPSA level distribution was analyzed. Results The incidence of TPSA> 4ng / ml in 6 cases (4.31 ~ 5.08ng / ml) was about 3.39%. There was no significant correlation between TPSA and age (r = 0.141, P = 0.061). Conclusion The incidence of TPSA in rural healthy elderly men over 50 years old in Luliang, Shanxi Province is high. It is necessary to carry out TPSA screening in routine physical examination. Whether the final conclusion needs further large sample study is needed.