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目的:探讨艾滋病病毒感染者/艾滋病患者(HIV/AIDS)生殖道高危型人乳头瘤病毒(HR-HPV)感染及宫颈病变的特点,为HIV/AIDS患者宫颈癌的防治研究提供线索和依据。方法:选取2009年4月至2012年7月就诊于我院的166例HIV/AIDS患者[HIV(+)组]与476例非HIV感染患者[HIV(-)组],比较两组患者的HR-HPV感染率及液基细胞学检测(TCT)检测结果。结果:HIV(+)组的HR-HPV感染率(38.55%,64/166)显著高于HIV(-)组(10.50%,50/476)(P<0.001)。HIV(+)组中20例行宫颈活检,其中13例(65.00%)发生CINⅠ以上病变;HIV(-)组中21例行宫颈活检,19例(90.48%)发生CINⅠ以上病变。HIV(+)组中HR-HPV(+)与HR-HPV(-)者的CD4<200cell/μl的比率分别为29.29%和17.48%,差异显著(P=0.03)。结论:HIV/AIDS患者感染HR-HPV的风险显著高于非HIV感染者,对HIV-HPV联合感染者应进行连续追踪观察。HIV/AIDS患者感染HR-HPV可能与免疫系统的破坏程度有关。
Objective: To investigate the characteristics of high risk human papillomavirus (HPV) and cervical lesions in the genital tract of people living with HIV / AIDS (HIV / AIDS) and to provide clues and evidences for the prevention and treatment of cervical cancer in HIV / AIDS patients. Methods: A total of 166 HIV / AIDS patients [HIV (+) group) and 476 non-HIV infected patients (HIV (-) group) were selected from April 2009 to July 2012 in our hospital. HR-HPV infection rate and liquid-based cytology (TCT) test results. Results: The HR-HPV infection rate in HIV (+) group was significantly higher than that in HIV (-) group (38.55%, 64/166) (10.50%, 50/476) (P <0.001). Cervical biopsy was performed in 20 cases of HIV (+) group, of which 13 cases (65.00%) had CINⅠ or higher lesions; 21 cases of cervical biopsy in HIV (-) group and 19 cases (90.48%) with CINⅠ or more. The ratio of CD4 <200cell / μl in HR-HPV (+) and HR-HPV (-) was 29.29% and 17.48% respectively in HIV (+) group, with significant difference (P = 0.03). Conclusion: The risk of HR-HPV infection in HIV / AIDS patients is significantly higher than that in non-HIV-infected patients, and the co-infection with HIV-HPV should be followed up continuously. Infection with HIV-HPV in HIV / AIDS patients may be related to the degree of damage to the immune system.