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目的:了解杭州余杭地区轮状病毒VP4基因型与轮状病毒肠炎肠道外损伤关系。方法:收集2011年7月-2012年6月杭州市余杭区第二人民医院5岁以下住院腹泻儿童粪便标本进行轮状病毒检测和P血清型分型,同时监测肝功、电解质、心肌酶谱等。结果:共收RV阳性标本137份,其中检出P[4]型83株,P[8]型41株。P[4]血清型患儿腹泻病程和呕吐持续时间显著长于P[8]血清型患儿(P<0.05);P[4]血清型患儿心肌损害和肝功损害的患病率以及谷丙转氨酶和磷酸肌酸激酶同工酶MB水平均显著高于P[8]血清型患儿(P<0.05)。结论:该地区轮状病毒肠炎RV VP4(P)血清型以P[4]和P[8]血清型为主,且P[4]型患儿临床表现较P[8]型患儿重。
Objective: To understand the relationship between rotavirus VP4 genotype and rotavirus enteropathy in Yuhang area of Hangzhou. Methods: From July 2011 to June 2012, rotavirus and P serotypes were collected from stool specimens of children under 5 years of age hospitalized in the Second People’s Hospital of Yuhang District, Hangzhou City, from July 2011 to June 2012. Liver function, electrolytes and myocardial enzymes Wait. Results: A total of 137 RV positive samples were collected, of which 83 were P [4] and 41 were P [8]. The duration and vomiting duration of diarrhea in P [4] serotype children were significantly longer than those in P [8] serotype children (P <0.05). The prevalence of myocardial damage and liver damage in P [4] ALT and MB creatine kinase MB levels were significantly higher than P [8] serotypes children (P <0.05). CONCLUSIONS: The RV VP4 (P) serotypes of rotavirus enteritis are predominantly P [4] and P [8] serotypes in this region, and the clinical manifestations in children with P [4] are more severe than those in P [8].