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目的探讨妊娠期补充钙及维生素 D对孕妇骨代谢及母乳钙含量的影响。方法对照观察服用钙及维生素 D前后血清钙、磷、骨钙素及初乳钙方面的变化。结果用药后血清钙、磷、骨钙素高于用药前 (P< 0.001)，用药组骨密度基本维持不变，而对照组随着孕龄的增加密度下降明显 (P< 0.01)。给药组初乳钙明显高于对照组 (P< 0.05)。结论孕期补钙加维生素 D有明显促进骨形成，抑制骨吸收和提高血清钙、磷、初乳钙的作用。
Objective To investigate the effects of calcium and vitamin D supplementation during pregnancy on bone metabolism and calcium in pregnant women. Methods The changes of serum calcium, phosphorus, osteocalcin and colostrum calcium before and after taking calcium and vitamin D were observed. Results After treatment, serum calcium, phosphorus and osteocalcin were higher than those before treatment (P <0.001). The BMD in the treatment group remained unchanged, while the control group decreased significantly with increasing gestational age (P <0.01). Colostrum calcium in the treatment group was significantly higher than that in the control group (P <0.05). Conclusion Calcium and vitamin D during pregnancy significantly promote bone formation, inhibit bone resorption and increase serum calcium, phosphorus, colostrum calcium.