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研究目的:调查体外受精(IVF)和单精子胞浆内注射(ICSI)孕育的学龄前单双胎子代在认知发展上是否存在显著性差异。创新要点:在严格匹配人口学资料的基础上区分早产儿和足月儿后,比较了两种辅助生育技术单双胎子代的认知发展水平。在排除早产和技术的影响后,双胎子代的智商仍显著低于单胎子代,为继续在临床推进单胚胎移植提供了新的证据。研究方法:共566名学龄前辅助生育技术子代学龄前儿童纳入本研究,分为4组:IVF-足月、IVF-早产、ICSI-足月和ICSI-早产,相同组内的单双胎子代的人口学数据严格匹配(见表1、3、5、7)后,采用中文版的韦氏儿童智力测验评估单双胎子代的智商水平(见表2、4、6、8)。重要结论:IVF足月双胎子代的认知发展水平显著低于足月单胎子代,而ICSI足月单双胎子代的认知发展水平无显著差异。对于早产子代来说,无论是孕育于IVF或ICSI,单胎和双胎的认知发展均无明显差异。
The purpose of this study was to investigate whether there is a significant difference in the cognitive development between pre-twins and single-twins progeny developed by in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). Innovative points: After the strict distinction between demographic data based on the distinction between premature children and term infants, compared the two assisted reproductive technology single and twin offspring cognitive development. After excluding the influence of premature birth and technology, the IQ of twins was still significantly lower than that of single fetuses, which provided new evidence for further clinical advancement of single embryo transfer. Methods: A total of 566 preschool assisted reproductive technology offspring of preschool children were enrolled in this study and divided into 4 groups: IVF-term, IVF-preterm, ICSI-term and ICSI-preterm, single and twin Generational demographic data are closely matched (see Tables 1, 3, 5 and 7). The Chinese version of Webster’s Intelligence Test was used to assess the IQ of single and twin offspring (see Tables 2, 4, 6 and 8). Important Conclusions: The cognitive development of IVF full-term twin offspring was significantly lower than that of full-term singleton offspring, while there was no significant difference in cognitive development between single-twin and single-fetus offspring of ICSI. For preterm offspring, there was no significant difference in cognitive development between singleton and twin births, either in IVF or ICSI.